MES Monohydrate

Excipient

ICH Q7 GMP Manufactured Product

MES Monohydrate

Low PVS, GMP, Excipient
Product Code: MESM-3222

Minimum Order Quantity: 250kg
Lead Time (if no stock): 3-6 months

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Product Code: MESM-3222

Suitable for use as a cGMP chemical in pharmaceutical manufacturing processes and products.

MES Monohydrate is a zwitterionic buffer that is not absorbed through cell membranes and is virtually transparent in UV light. MES is a buffering agent used in many biological and biochemical applications. It is also used as a running buffer for denaturing gel electrophoresis. The characteristics of low UV absorptivity, minimal reactivity, stable pH and solubility in water allow MES Monohydrate to be a Good’s buffer.

CAS #: 145224-94-8
Formula: C₆H₁₃NO₄S·H₂O
F.W.: 213.25 g/mol
pH (0.5M): 3.5 - 4.5
pK_a: 5.9 - 6.3

Product Specifications

ANALYSIS

SPECIFICATIONS

Absorbance (1M)

260 nm

280 nm

< = 0.1000 a.u.

Appearance and Color

White Crystalline Powder

Assay

> = 99.5%

Chloride

< = 50 ppm

Color (1M, Alkaline)

Colorless

Enzymes

DNase

RNase

Protease

None Detected

Identification, IR

Conforms to Reference Standard

Loss on Drying, 130°C

7 - 10%

pH (5%)

3.1 - 3.5

pH (1.0M)

2.7 – 3.7

pH (0.5M)

2.5 – 4.5

pK_a

5.9 – 6.3

PVS Limit Test

< = 1 ppm

Residue on Ignition

< = 0.05%

Solubility (5%)

Passes Test

Sulfate

< = 50 ppm

Trace Metals

Arsenic (As)

Copper (Cu)

Iron (Fe)

Lead (Pb)

< = 2 ppm

Water, KF

7.9 – 8.9%

Printable Version

Key Product Features:

The manufacturing of MES Monohydrate, MESM-3222 is performed at BioSpectra’s Bangor, PA facility.
Appears as a white crystalline powder
Manufactured in accordance with ICH Q7
Manufactured in an enzyme free, hormone free, and animal free environment
Contains no known major food allergens (as defined by FDA and WHO)
The final product and its raw materials are not derived from nor come into contact with animal parts, animal products, and/or animal byproducts or derivatives.
Is not subject to genetic modification
Synonyms: 2-(N-Morpholino) Ethane Sulfonic Acid; 4-Morpholineethanesulfonic Acid Monohydrate

Shelf-Life Policy:

Unless otherwise noted on the Shelf-Life Statement and CoA, this product has a 2-year retest date supported by a 3-year ICH Q1 Stability Study (if one is completed).

Storage & Shipping:

Refer to SDS.

Package Sizes:

10kg, 25kg, and 50kg

Bulk GMP Fine Chemicals exclusively manufactured in North America

American Manufactured - FDA Registered GMP Facilities: Parenteral Excipients, GMP Small Molecule Intermediates, GMP Biological Buffers, Parenteral Carbohydrates, GMP Chlorinated Amino Acids, GMP Solutions in Sterile Single Use Packaging and other Reagent & GMP Fine Chemicals.