GMP Manufactured Process Chemical
Guanidine HCL (6M) Solution
Guanidine Hydrochloride 6M solution can be used to denature proteins which become randomly coiled with no residual structure. This concentration is also used to decrease enzyme activity. The denatured proteins can be modified or analyzed using mass spectrometry, electrophoresis and enzymatic digests. As a chaotropic agent, Guanidine Hydrochloride solution is also used to break the hydrogen bonds in the structure of proteins and increase the solubility of hydrophobic molecules.
CAS #: 50-01-1
Formula: CH5N3 • HCl
Sol. In H20 (g/L): 573
F.W.: 95.53 g/mol
pH @ 20oC: 4.5 - 6.0
pKa @ 25oC: 13.6
Product Specifications
| ANALYSIS | SPECIFICATIONS | ||
|---|---|---|---|
|
Clear, Colorless Liquid | ||
|
< 10 ppm | ||
|
Passes Test | ||
|
≤ 3 ppm | ||
|
5.5-6.5 M |
Printable Version
General Product Description:
- The manufacturing of Guanidine Hydrochloride GHCL-4120 is performed at BioSpectra’s Stroudsburg, PA facility utilizing dedicated equipment. Equipment used in the manufacturing of GHCL-4120 is cleaned in accordance with BioSpectra’s Cleaning Validation Plan.
- Guanidine Hydrochloride 6M is a clear colorless solution.
- There are no known major food allergens (as defined by FDA and WHO) in the manufacture of this product.
- BioSpectra certifies that all Guanidine Hydrochloride 6M GHCL-4120 manufactured at BioSpectra and its raw materials are not derived from or come in contact with animal parts, products, and/or byproducts.
- Guanidine Hydrochloride 6M manufactured at BioSpectra and any raw materials used in the manufacture of
- Guanidine Hydrochloride 6M at BioSpectra are not subject to genetic modification.
- Synonyms: Guanidine Monohydrochloride, Guanidinium Chloride, Guanidinium Hydrochloride.
- Manufactured with USP grade purified water.
GMP Compliance:
Bio Pharma Grade Guanidine Hydrochloride 6M, GHCL-4120 is suitable for use as a process chemical. It is manufactured in accordance with the IPEC- PQG Joint Good Manufacturing Practice Guide. This grade of Guanidine Hydrochloride is not suitable to be used as an Active Pharmaceutical Ingredient, Drug, Drug Product or Household Item.
Retest Date:
The recommended retest period for Guanidine Hydrochloride 6M is two years from the date of manufacture.
Storage and Shipping Conditions:
Ship and Store in ambient temperature.
Package Sizes:
Available in 200L drums and totes.
Bulk GMP Fine Chemicals exclusively manufactured in North America
American Manufactured - FDA Registered GMP Facilities: Parenteral Excipients, GMP Small Molecule Intermediates, GMP Biological Buffers, Parenteral Carbohydrates, GMP Chlorinated Amino Acids, GMP Solutions in Sterile Single Use Packaging and other Reagent & GMP Fine Chemicals.