GMP Biotech Product
BIS-TRIS BIOTECH
LBLE*, GMP
*Low Bioburden, Low Endotoxin
COAs Spec Sheet
Product Code: BTRI-4250
Intended for Use in Biopharmaceutical & Biotechnological Applications and Products
Intended to be used as a high purity, GMP Reagent Grade. BIS-TRIS is a zwitterionic biological “Goods” buffer often used in biological pharmaceutical manufacturing and biochemistry for extraction, separation and purification, as well as an intermediate in synthetic reactions for both proteins and nucleic acid. BIS-TRIS is also used as a process aid in peptide synthesis. It can also be used as a scavenger agent for metal ions such as Cu and Pb.
CAS #: 6976-37-0
Formula: C8H19NO5
pH @ 25°C: 6.3 - 6.7
Melting Point/Range: 100 - 105°C
F.W.: 209.24 g/mol
Product Specifications:
| Analysis | Specifications | ||
|---|---|---|---|
|
None Detected None Detected None Detected |
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|
≤ 5 ppm ≤ 500 ppm ≤ 10 ppm ≤ 500 ppm |
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White Crystalline Powder |
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|
99.0% - 101.0% |
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|
≤ 100 CFU/g ≤ 100 CFU/g |
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|
Chloride |
< 0.005% |
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|
Endotoxin |
≤ 50 EU/g | ||
|
≤ 0.04 a.u. ≤ 0.02 a.u. |
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≤ 3ppm |
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Conforms to Reference Standard |
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≤ 3ppm |
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|
≤ 1.0% |
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|
Melting Point |
100 – 105°C |
||
| pH (1% aqueous) |
8.8 – 9.8 |
||
| pKa @ 25° C |
6.3 – 6.7 |
||
|
Residue on Ignition (ROI) |
≤ 0.1% |
||
|
Solubility 0.1M in H2O |
Clear & Complete | ||
|
Water (KF) |
≤ 1.0% | ||
|
Ammonia (NH4) |
≤ 0.5% | ||
|
Sulfate (SO4) |
≤ 0.05% ≤ 0.05% |
Printable Version
General Product Description:
Molecular Formula: C8H19NO5
Molecular Weight: 209.24 g/mol
CAS Number: 6976-37-0
BIS-TRIS Biotech:
- Appears as a white crystalline product.
- Is manufactured under an ICH-Q7 Quality Managed cGMP System
- Manufactured in an enzyme free, hormone free and animal free environment
- Has no known major food allergens (as defined by FDA and WHO)
- The final product nor its raw materials are not derived from nor come into contact with animals, animal parts, animal products, and/or animal byproducts or derivatives.
- Is not subject to genetic modification
- Synonyms: 2,2-Bis(hydroxymethyl)-2,2’,2’’- nitrile tri ethanol; Bis(2-hydroxyethyl) amino tris (hydroxymethyl)methane
Shelf Life Policy:
Three-year expiry from the date of manufacture.
Storage and Shipping Conditions:
Please refer to the SDS for storage and shipping conditions.
Package Sizes:
100g, 500g, 1kg, 5kg, 10kg, 25kg, 50kg.
Bulk GMP Fine Chemicals exclusively manufactured in North America
American Manufactured - FDA Registered GMP Facilities: Parenteral Excipients, GMP Small Molecule Intermediates, GMP Biological Buffers, Parenteral Carbohydrates, GMP Chlorinated Amino Acids, GMP Solutions in Sterile Single Use Packaging and other Reagent & GMP Fine Chemicals.